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In 2014, Takayama et al. [38] 1st attempted to elucidate the in vitro metabolism of ADB-FUBINACA by analysing the metabolites made by the action from the cytochrome P450 enzymes right after 1 h of incubation with human liver microsomes. Utilizing UPLC/ESI-MS/MS, the authors discovered an individual metabolite, resulting from oxidation of your NI’